PBPK FAQs

The 2000 Edition of the NFPA 2001-Standard on Clean Agent Fire Extinguishing Systems incorporates the use of pharmacokinetics and the physiologically-based pharmacokinetic (PBPK) model as an option for determining allowable exposure times for halocarbon agents such as FM-200 and FE-227 (HFC-227ea), FE-25 (HFC-125), FE-36 (HFC-236fa), and CF3I (FIC-13I1). Although the use of pharmacokinetic modeling is quite common for determining safe exposure to chemicals in air, water and the workplace, this is the first use of PBPK in a fire suppression agent standard. In an effort to provide a basic understanding of the science behind the use of PBPK, we have prepared answers to some of the basic and most frequently asked questions.

• Read More